Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...

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Bibliografiska uppgifter
Huvudupphovsmän: Bermejo, Rodrigo, Doksani, Ylli, Capra, Thelma, Katou, Yuki-Mori, Tanaka, Hirokazu, Shirahige, Katsuhiko, Foiani, Marco
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2007
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1935030/
https://ncbi.nlm.nih.gov/pubmed/17671091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.432107
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