The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and dormant origin firing due to checkpoint defects are rescued in checkpoint mutant...

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Hlavní autoři: Bermejo, Rodrigo, Capra, Thelma, Jossen, Rachel, Colosio, Arianna, Frattini, Camilla, Carotenuto, Walter, Cocito, Andrea, Doksani, Ylli, Klein, Hannah, Gómez-González, Belén, Aguilera, Andrés, Katou, Yuki, Shirahige, Katsuhiko, Foiani, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160733/
https://ncbi.nlm.nih.gov/pubmed/21784245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.033
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