Differential assembly diversifies GABA(A) receptor structures and signalling

Type-A γ-aminobutyric acid receptors (GABA(A)Rs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits( 1,2 ) and are modulated by essential medicines including general anaesthetics and benzodiazepines( 3 ). Human GABA(A)R subunits are encoded by 19...

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Udgivet i:Nature
Main Authors: Sente, Andrija, Desai, Rooma, Naydenova, Katerina, Malinauskas, Tomas, Jounaidi, Youssef, Miehling, Jonas, Zhou, Xiaojuan, Masiulis, Simonas, Hardwick, Steven W., Chirgadze, Dimitri Y., Miller, Keith W., Aricescu, A. Radu
Format: Artigo
Sprog:Inglês
Udgivet: 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612593/
https://ncbi.nlm.nih.gov/pubmed/35355020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-04517-3
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