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A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes

Rotaxanes can display molecular chirality solely due to the mechanical bond between the axle and encircling macrocycle without the presence of covalent stereogenic units. However, the synthesis of such molecules remains challenging. We have discovered a combination of reaction partners that function...

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Bibliographic Details
Published in:Nat Chem
Main Authors: de Juan, Alberto, Lozano, David, Heard, Andrew W., Jinks, Michael A., Suarez, Jorge Meijide, Tizzard, Graham J., Goldup, Stephen M.
Format: Artigo
Language:Inglês
Published: 2022
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612332/
https://ncbi.nlm.nih.gov/pubmed/34845345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-021-00825-9
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