SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation

In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge, the necessity to erase and reset genomic methylation( 1 ). In the male germline RNA-directed DNA methylation silences young active transposable elements (TEs)( 2–4 ). The PIWI protein MIWI2 (...

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Published in:Nature
Main Authors: Zoch, Ansgar, Auchynnikava, Tania, Berrens, Rebecca V., Kabayama, Yuka, Schöpp, Theresa, Heep, Madeleine, Vasiliauskaitė, Lina, Pérez-Rico, Yuvia A., Cook, Atlanta G., Shkumatava, Alena, Rappsilber, Juri, Allshire, Robin C., O’Carroll, Dónal
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612247/
https://ncbi.nlm.nih.gov/pubmed/32674113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2557-5
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