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A surface-free design for phase I dual-agent combination trials

In oncology, there is a growing number of therapies given in combination. Recently, several dose-finding designs for Phase I dose-escalation trials for combinations were proposed. The majority of novel designs use a pre-specified parametric model restricting the search of the target combination to a...

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Bibliografski detalji
Izdano u:Stat Methods Med Res
Glavni autori: Mozgunov, Pavel, Gasparini, Mauro, Jaki, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612168/
https://ncbi.nlm.nih.gov/pubmed/32338145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280220919450
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