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An information theoretic phase I–II design for molecularly targeted agents that does not require an assumption of monotonicity

For many years phase I and phase II clinical trials have been conducted separately, but there has been a recent shift to combine these phases. Although a variety of phase I–II model‐based designs for cytotoxic agents have been proposed in the literature, methods for molecularly targeted agents (TAs)...

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Detalhes bibliográficos
Publicado no:J R Stat Soc Ser C Appl Stat
Main Authors: Mozgunov, Pavel, Jaki, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472641/
https://ncbi.nlm.nih.gov/pubmed/31007292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12293
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