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A stochastically curtailed two-arm randomised phase II trial design for binary outcomes

Randomised controlled trials are considered the gold standard in trial design. However, phase II oncology trials with a binary outcome are often single-arm. Although a number of reasons exist for choosing a single-arm trial, the primary reason is that single-arm designs require fewer participants th...

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Vydáno v:Pharm Stat
Hlavní autoři: Law, Martin, Grayling, Michael J., Mander, Adrian P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612167/
https://ncbi.nlm.nih.gov/pubmed/32860470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.2067
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