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A stochastically curtailed two-arm randomised phase II trial design for binary outcomes

Randomised controlled trials are considered the gold standard in trial design. However, phase II oncology trials with a binary outcome are often single-arm. Although a number of reasons exist for choosing a single-arm trial, the primary reason is that single-arm designs require fewer participants th...

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Pubblicato in:Pharm Stat
Autori principali: Law, Martin, Grayling, Michael J., Mander, Adrian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612167/
https://ncbi.nlm.nih.gov/pubmed/32860470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.2067
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