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Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables

We describe and compare two methods for the group sequential design of two-arm experiments with Poisson distributed data, which are based on a normal approximation and exact calculations respectively. A framework to determine near-optimal stopping boundaries is also presented. Using this framework,...

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Publicat a:Commun Stat Theory Methods
Autors principals: Grayling, Michael J., Wason, James M. S., Mander, Adrian P.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116540/
https://ncbi.nlm.nih.gov/pubmed/33408437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03610926.2019.1628273
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