T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

The efficacy of adoptive cell therapy for solid tumours is hampered by the poor accumulation of the transferred T cells in tumour tissue. Here, we show that the forced expression of the C-X-C chemokine receptor type 6 (CXCR6, whose ligand is highly expressed by human and murine pancreatic cancer cel...

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書誌詳細
出版年:Nat Biomed Eng
主要な著者: Lesch, Stefanie, Blumenberg, Viktoria, Stoiber, Stefan, Gottschlich, Adrian, Ogonek, Justyna, Cadilha, Bruno L., Dantes, Zahra, Rataj, Felicitas, Dorman, Klara, Lutz, Johannes, Karches, Clara H., Heise, Constanze, Kurzay, Mathias, Larimer, Benjamin M., Grassmann, Simon, Rapp, Moritz, Nottebrock, Alessia, Kruger, Stephan, Tokarew, Nicholas, Metzger, Philipp, Hoerth, Christine, Benmebarek, Mohamed-Reda, Dhoqina, Dario, Grünmeier, Ruth, Seifert, Matthias, Oener, Arman, Umut, Öykü, Joaquina, Sandy, Vimeux, Lene, Tran, Thi, Hank, Thomas, Baba, Taisuke, Huynh, Duc, Megens, Remco TA., Janssen, Klaus-Peter, Jastroch, Martin, Lamp, Daniel, Ruehland, Svenja, Di Pilato, Mauro, Pruessmann, Jasper N., Thomas, Moritz, Marr, Carsten, Ormanns, Steffen, Reischer, Anna, Hristov, Michael, Tartour, Eric, Donnadieu, Emmanuel, Rothenfusser, Simon, Duewell, Peter, König, Lars M., Schnurr, Max, Subklewe, Marion, Liss, Andrew S., Halama, Niels, Reichert, Maximilian, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611996/
https://ncbi.nlm.nih.gov/pubmed/34083764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-021-00737-6
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