T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

The efficacy of adoptive cell therapy for solid tumours is hampered by the poor accumulation of the transferred T cells in tumour tissue. Here, we show that the forced expression of the C-X-C chemokine receptor type 6 (CXCR6, whose ligand is highly expressed by human and murine pancreatic cancer cel...

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Publicado en:Nat Biomed Eng
Main Authors: Lesch, Stefanie, Blumenberg, Viktoria, Stoiber, Stefan, Gottschlich, Adrian, Ogonek, Justyna, Cadilha, Bruno L., Dantes, Zahra, Rataj, Felicitas, Dorman, Klara, Lutz, Johannes, Karches, Clara H., Heise, Constanze, Kurzay, Mathias, Larimer, Benjamin M., Grassmann, Simon, Rapp, Moritz, Nottebrock, Alessia, Kruger, Stephan, Tokarew, Nicholas, Metzger, Philipp, Hoerth, Christine, Benmebarek, Mohamed-Reda, Dhoqina, Dario, Grünmeier, Ruth, Seifert, Matthias, Oener, Arman, Umut, Öykü, Joaquina, Sandy, Vimeux, Lene, Tran, Thi, Hank, Thomas, Baba, Taisuke, Huynh, Duc, Megens, Remco TA., Janssen, Klaus-Peter, Jastroch, Martin, Lamp, Daniel, Ruehland, Svenja, Di Pilato, Mauro, Pruessmann, Jasper N., Thomas, Moritz, Marr, Carsten, Ormanns, Steffen, Reischer, Anna, Hristov, Michael, Tartour, Eric, Donnadieu, Emmanuel, Rothenfusser, Simon, Duewell, Peter, König, Lars M., Schnurr, Max, Subklewe, Marion, Liss, Andrew S., Halama, Niels, Reichert, Maximilian, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611996/
https://ncbi.nlm.nih.gov/pubmed/34083764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-021-00737-6
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