Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges

CriPec® technology enables the generation of drug-entrapped biodegradable core-crosslinked polymeric micelles (CCPM) with high drug loading capacity, tailorable size and drug release kinetics. Docetaxel-entrapped CCPM, also referred to as CPC634, have demonstrated favorable pharmacokinetics, tolerab...

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Udgivet i:Biotechnol J
Main Authors: Ojha, Tarun, Hu, Qizhi, Colombo, Claudio, Wit, Jan, van Geijn, Michiel, van Steenbergen, Mies J., Bagheri, Mahsa, Königs-Werner, Hiltrud, Buhl, Eva Miriam, Bansal, Ruchi, Shi, Yang, Hennink, Wim E., Storm, Gert, Rijcken, Cristianne J.F., Lammers, Twan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611944/
https://ncbi.nlm.nih.gov/pubmed/33484630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.202000212
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