Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles

Core-crosslinked polymeric micelles (CCPM) based on PEG-b-pHPMA-lactate are clinically evaluated for the treatment of cancer. We macroscopically and microscopically investigated the biodistribution and target site accumulation of CCPM. To this end, fluorophore-labeled CCPM were intravenously injecte...

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Veröffentlicht in:J Control Release
Hauptverfasser: Biancacci, Ilaria, Sun, Qingxue, Möckel, Diana, Gremse, Felix, Rosenhain, Stefanie, Kiessling, Fabian, Bartneck, Matthias, Hu, Qizhi, Thewissen, Marielle, Storm, Gert, Hennink, Wim E., Shi, Yang, Rijcken, Cristianne J.F., Lammers, Twan, Sofias, Alexandros Marios
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611891/
https://ncbi.nlm.nih.gov/pubmed/33010332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.09.046
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