A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen

We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We re-expressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which endogenous FAK had been deleted, genetically fixi...

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Publicat a:Mol Cancer Ther
Autors principals: Dawson, John C., Serrels, Bryan, Byron, Adam, Muir, Morwenna T., Makda, Ashraff, García-Muñoz, Amaya, von Kriegsheim, Alex, Lietha, Daniel, Carragher, Neil O., Frame, Margaret C.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611632/
https://ncbi.nlm.nih.gov/pubmed/31784455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0330
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