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Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5376188/ https://ncbi.nlm.nih.gov/pubmed/28362576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23172 |
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