Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1

We recently reported that a complex between focal adhesion kianse (FAK) and the molecular scaffold RACK1 controlled nascent integrin adhesion formation and cell polarization, via peripheral recruitment of the cAMP - degrading PDE4D5 isoform. Here we review and extend these studies by demonstrating t...

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Bibliografiske detaljer
Main Authors: Serrels, Bryan, Sandilands, Emma, Frame, Margaret C
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116620/
https://ncbi.nlm.nih.gov/pubmed/21686284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.1.15137
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