CDK4 regulates lysosomal function and mTORC1 activation to promote cancer cell survival

Cyclin-dependent kinase 4 (CDK4) is well-known for its role in regulating the cell cycle, however, its role in cancer metabolism, especially mTOR signaling, is undefined. In this study, we established a connection between CDK4 and lysosomes, an emerging metabolic organelle crucial for mTORC1 activat...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Martínez-Carreres, Laia, Puyal, Julien, Leal-Esteban, Lucía C., Orpinell, Meritxell, Castillo-Armengol, Judit, Giralt, Albert, Dergai, Oleksandr, Moret, Catherine, Barquissau, Valentin, Nasrallah, Anita, Pabois, Angélique, Zhang, Lianjun, Romero, Pedro, Lopez-Mejia, Isabel C., Fajas, Lluis
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611450/
https://ncbi.nlm.nih.gov/pubmed/31395606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0708
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