Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA Polymerase

The MYC protein is an oncogenic transcription factor that binds globally to active promoters and promotes transcriptional elongation by RNAPII(1,2). Deregulated expression of the paralogous MYCN protein drives the development of neuronal and neuroendocrine tumors and is often associated with a parti...

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Dades bibliogràfiques
Publicat a:Nature
Autors principals: Herold, Steffi, Kalb, Jacqueline, Büchel, Gabriele, Ade, Carsten P., Baluapuri, Apoorva, Xu, Jiajia, Koster, Jan, Solvie, Daniel, Carstensen, Anne, Klotz, Christina, Rodewald, Sabrina, Schülein-Völk, Christina, Dobbelstein, Matthias, Wolf, Elmar, Molenaar, Jan, Versteeg, Rogier, Walz, Susanne, Eilers, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611299/
https://ncbi.nlm.nih.gov/pubmed/30894746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1030-9
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