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Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cel...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2695754/ https://ncbi.nlm.nih.gov/pubmed/19525400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901418106 |
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