The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

High polyamine (PA) levels and ornithine decarboxylase (ODC) over-expression are well-known phenomena in many aggressive cancer types. We analyzed the expression of ODC and ODC-activity regulating genes antizymes 1-3 (OAZ1-3) and AZ inhibitors 1-2 (AZ-IN1-2) in human neuroblastoma (NB) tumors and co...

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Main Authors: Geerts, Dirk, Koster, Jan, Albert, David, Koomoa, Dana-Lynn T., Feith, David J., Pegg, Anthony E., Volckmann, Richard, Caron, Huib, Versteeg, Rogier, Bachmann, André S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847573/
https://ncbi.nlm.nih.gov/pubmed/19960435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25074
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