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Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis. Polyamines regulate ODC levels by a feedback mechanism mediated by ODC antizyme (OAZ). Higher cellular polyamine levels trigger the sy...
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| Publié dans: | Microb Cell |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Shared Science Publishers OG
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5349141/ https://ncbi.nlm.nih.gov/pubmed/28357293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2015.06.206 |
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