Repression of the Type I Interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in Pancreatic Ductal Adenocarcinoma

MYC is implicated in the development and progression of Pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumour development has been difficult to define. We used modestly elevated expression of human MYC, driven from the Rosa26 locus, to investigate the pancreat...

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izdano v:Cancer Discov
Main Authors: Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Björn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A., Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew V., Carlin, Leo M., Coffelt, Seth B., Sansom, Owen J., Morton, Jennifer P., Murphy, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611248/
https://ncbi.nlm.nih.gov/pubmed/32200350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0620
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