Repression of the Type I Interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in Pancreatic Ductal Adenocarcinoma

MYC is implicated in the development and progression of Pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumour development has been difficult to define. We used modestly elevated expression of human MYC, driven from the Rosa26 locus, to investigate the pancreat...

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Publicat a:Cancer Discov
Autors principals: Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Björn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A., Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew V., Carlin, Leo M., Coffelt, Seth B., Sansom, Owen J., Morton, Jennifer P., Murphy, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611248/
https://ncbi.nlm.nih.gov/pubmed/32200350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0620
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