JAK2 exon 12 mutations in cases with JAK2V617F-negative polycythemia vera and primary myelofibrosis

Molecular detection of JAK2 mutation (V617F or exon 12) is included as a major diagnostic criterion for polycythemia vera (PV) by the WHO 2016 guidelines. JAK2 exon 12 mutations are seen in about 2–5% of JAK2V617F-negative cases of PV. Mutations in JAK2 cause constitutive activation of JAK-STAT path...

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Udgivet i:Ann Hematol
Main Authors: Maddali, Madhavi, Kulkarni, Uday Prakash, Ravindra, Niveditha, Jajodia, Ekta, Arunachalam, Arun Kumar, Suresh, Hemamalini, Venkatraman, Arvind, George, Biju, Mathews, Vikram, Balasubramanian, Poonkuzhali
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611239/
https://ncbi.nlm.nih.gov/pubmed/32277273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-020-04004-7
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