JAK2(V617F) allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy

In a series of 105 patients with polycythemia vera, we retrospectively determined whether the JAK2(V617F) mutation correlated with severity of disease phenotype. Higher JAK2(V617F) allele burden correlated with more advanced myelofibrosis, greater splenomegaly, and higher white blood cell count, but...

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Detalhes bibliográficos
Main Authors: Silver, Richard T., Vandris, Katherine, Wang, Y. Lynn, Adriano, Fernando, Jones, Amy V., Christos, Paul J., Cross, Nicholas C.P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626091/
https://ncbi.nlm.nih.gov/pubmed/20650526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.06.017
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