Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA Polymerase II (Pol II), causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the severe consequence of these transcription-bl...

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Τόπος έκδοσης:Nat Cell Biol
Κύριοι συγγραφείς: Geijer, Marit E, Zhou, Di, Selvam, Kathiresan, Steurer, Barbara, Mukherjee, Chirantani, Evers, Bastiaan, Cugusi, Simona, van Toorn, Marvin, van der Woude, Melanie, Janssens, Roel C., Kok, Yannick P, Gong, Wenzhi, Raams, Anja, Lo, Calvin SY, Lebbink, Joyce HG, Geverts, Bart, Plummer, Dalton A, Bezstarosti, Karel, Theil, Arjan F, Mitter, Richard, Houtsmuller, Adriaan B, Vermeulen, Wim, Demmers, Jeroen AA, Li, Shisheng, van Vugt, Marcel ATM, Lans, Hannes, Bernards, René, Svejstrup, Jesper Q, Chaudhuri, Arnab Ray, Wyrick, John J, Marteijn, Jurgen A
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2021
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611218/
https://ncbi.nlm.nih.gov/pubmed/34108662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-021-00692-z
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