Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis

PURPOSE: Therapies directed to specific molecular targets are still unmet for triple-negative breast cancer (TNBC) patients. Deubiquitinases (DUBs) are emerging drug targets. The identification of a highly active DUBs in TNBC may lead to novel therapies. EXPERIMENTAL DESIGN: Using DUB activity probe...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Liu, Sijia, González-Prieto, Román, Zhang, Mengdi, Geurink, Paul P., Kooij, Raymond, Iyengar, Prasanna Vasudevan, van Dinther, Maarten, Bos, Erik, Zhang, Xiaobing, Le Dévédec, Sylvia, van de Water, Bob, Koning, Roman I., Zhu, Hong-Jian, Mesker, Wilma, Vertegaal, Alfred, Ovaa, Huib, Zhang, Long, Martens, John W. M., ten Dijke, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611208/
https://ncbi.nlm.nih.gov/pubmed/31857432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1373
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