Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors

The ubiquitin-proteasome system (UPS) plays an important role in maintaining protein homeostasis by degrading intracellular proteins. In the proteasome, poly-ubiquitinated proteins are deubiquitinated by three deubiquitinases (DUBs) associated with 19S regulatory particle before degradation via 20S...

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Библиографические подробности
Опубликовано в: :Bioorg Med Chem
Главные авторы: Arachchige, Harshani S. Gurusingha, Mudiyanselage, Poornima D. H. Herath, VanHecke, Garrett C., Patel, Kush, Cheaito, Hassan A., Dou, Q. Ping, Ahn, Young-Hoon
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880549/
https://ncbi.nlm.nih.gov/pubmed/33341501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115931
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