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A role for VCP/p97 in the processing of drug-stabilised TOP2-DNA covalent complexes
DNA topoisomerase II (TOP2) poisons induce protein-DNA crosslinks termed TOP2-DNA covalent complexes, in which TOP2 remains covalently bound to each end of an enzyme-induced double strand DNA break (DSB) via a 5’-phosphotyrosyl bond. Repair of the enzyme-induced DSB first requires the removal of the...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611185/ https://ncbi.nlm.nih.gov/pubmed/33941661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.121.000262 |
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