Tumor cell-derived Angiopoietin-2 promotes metastasis in melanoma

The Angiopoietin (Angpt)-TIE signaling pathway controls vascular maturation and maintains the quiescent phenotype of resting vasculature. The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believed to be exclusively produced by endothelial cells, disrupting constitutive ANGPT1-TIE2 sign...

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Publicat a:Cancer Res
Autors principals: Pari, Ashik Ahmed Abdul, Singhal, Mahak, Hübers, Corinne, Mogler, Carolin, Schieb, Benjamin, Gampp, Anja, Gengenbacher, Nicolas, Reynolds, Louise E., Terhardt, Dorothee, Géraud, Cyrill, Utikal, Jochen, Thomas, Markus, Goerdt, Sergij, Hodivala-Dilke, Kairbaan, Augustin, Hellmut G., Felcht, Moritz
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611175/
https://ncbi.nlm.nih.gov/pubmed/32303578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2660
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