Tumor cell-derived Angiopoietin-2 promotes metastasis in melanoma

The Angiopoietin (Angpt)-TIE signaling pathway controls vascular maturation and maintains the quiescent phenotype of resting vasculature. The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believed to be exclusively produced by endothelial cells, disrupting constitutive ANGPT1-TIE2 sign...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Pari, Ashik Ahmed Abdul, Singhal, Mahak, Hübers, Corinne, Mogler, Carolin, Schieb, Benjamin, Gampp, Anja, Gengenbacher, Nicolas, Reynolds, Louise E., Terhardt, Dorothee, Géraud, Cyrill, Utikal, Jochen, Thomas, Markus, Goerdt, Sergij, Hodivala-Dilke, Kairbaan, Augustin, Hellmut G., Felcht, Moritz
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611175/
https://ncbi.nlm.nih.gov/pubmed/32303578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2660
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