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Glypicans shield the Wnt lipid moiety to enable signalling at a distance

A relatively small number of proteins have been suggested to act as morphogens, signalling molecules that spread within tissues to organize cell fate specification during development and tissue repair. Among them are Wnt proteins, which carry a palmitoleate moiety that is essential for signalling ac...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: McGough, Ian J., Vecchia, Luca, Bishop, Benjamin, Malinauskas, Tomas, Beckett, Karen, Joshi, Dhira, O'Reilly, Nicola, Siebold, Christian, Jones, E. Yvonne, Vincent, Jean-Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610841/
https://ncbi.nlm.nih.gov/pubmed/32699409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2498-z
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