Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Targeted gene editing in hematopoietic stem cells (HSCs) is a promising treatment for several diseases. However, the limited efficiency of homology-directed repair (HDR) in HSCs and the unknown impact of the procedure on clonal composition and dynamics upon transplantation have hampered clinical tra...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Ferrari, Samuele, Jacob, Aurelien, Beretta, Stefano, Unali, Giulia, Albano, Luisa, Vavassori, Valentina, Cittaro, Davide, Lazarevic, Dejan, Brombin, Chiara, Cugnata, Federica, Kajaste-Rudnitski, Anna, Merelli, Ivan, Genovese, Pietro, Naldini, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610558/
https://ncbi.nlm.nih.gov/pubmed/32601433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0551-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados