DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats

The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s) of...

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Bibliografiset tiedot
Julkaisussa:Neurotherapeutics
Päätekijät: Sharma, Puneet K., Wells, Lisa, Rizzo, Gaia, Elson, Joanna L., Passchier, Jan, Rabiner, Eugenii A., Gunn, Roger N., Dexter, David T., Pienaar, Ilse S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer International Publishing 2020
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609798/
https://ncbi.nlm.nih.gov/pubmed/31965550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00830-4
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