DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats

The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s) of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neurotherapeutics
Hlavní autoři: Sharma, Puneet K., Wells, Lisa, Rizzo, Gaia, Elson, Joanna L., Passchier, Jan, Rabiner, Eugenii A., Gunn, Roger N., Dexter, David T., Pienaar, Ilse S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609798/
https://ncbi.nlm.nih.gov/pubmed/31965550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00830-4
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky