Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

The Nrf2 transcription factor is a key regulator of redox reactions and considered the main target for the multiple sclerosis (MS) drug dimethyl fumarate (DMF). However, exploration of additional Nrf2-activating compounds is motivated, since DMF displays significant off-target effects and has a rela...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Carlström, Karl E., Chinthakindi, Praveen K., Espinosa, Belén, Al Nimer, Faiez, Arnér, Elias S. J., Arvidsson, Per I., Piehl, Fredrik, Johansson, Katarina
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609514/
https://ncbi.nlm.nih.gov/pubmed/32394330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00855-0
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