Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard

In many mammals, genomic sites for recombination are determined by the histone methyltransferase PRMD9. Some mouse strains lacking PRDM9 are infertile, but instances of fertility or semifertility in the absence of PRDM9 have been reported in mice, canines, and a human female. Such findings raise the...

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Udgivet i:Sci Adv
Main Authors: Powers, Natalie R., Dumont, Beth L., Emori, Chihiro, Lawal, Raman Akinyanju, Brunton, Catherine, Paigen, Kenneth, Handel, Mary Ann, Bolcun-Filas, Ewelina, Petkov, Petko M., Bhattacharyya, Tanmoy
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608834/
https://ncbi.nlm.nih.gov/pubmed/33097538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb6606
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