The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation

The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles in developmental and cellular processes. Their enzymatic activities are stimulated by a regulatory protein Dnmt3L (Dnmt3-like) in vitro. However, genetic evidence indicates that Dnmt3L functions predominantly as a regulator of D...

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Publicado en:Genes Dev
Autores principales: Zeng, Yang, Ren, Ren, Kaur, Gundeep, Hardikar, Swanand, Ying, Zhengzhou, Babcock, Lance, Gupta, Esha, Zhang, Xing, Chen, Taiping, Cheng, Xiaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608744/
https://ncbi.nlm.nih.gov/pubmed/33004415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341925.120
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