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The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles in developmental and cellular processes. Their enzymatic activities are stimulated by a regulatory protein Dnmt3L (Dnmt3-like) in vitro. However, genetic evidence indicates that Dnmt3L functions predominantly as a regulator of D...
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| Publicado en: | Genes Dev |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7608744/ https://ncbi.nlm.nih.gov/pubmed/33004415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341925.120 |
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