The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are implicated in many diseases including cancer. In mammals, mitophagy is mediated by BNIP3L (also known as NIX) that is a dual regulator of mitochondrial turnover and programmed...

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Udgivet i:Acta Pharmacol Sin
Main Authors: Hao, Bing-bing, Li, Xiao-jing, Jia, Xing-long, Wang, Yu-xing, Zhai, Lin-hui, Li, Duan-zhuo, Liu, Jie, Zhang, Die, Chen, Yu-lu, Xu, Yong-hu, Lee, Sang-kyu, Xu, Guo-feng, Chen, Xiao-hua, Dang, Yong-jun, Liu, Bin, Tan, Min-jia
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608331/
https://ncbi.nlm.nih.gov/pubmed/32210356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-0367-9
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