A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer

Therapeutic targeting of advanced or metastatic non-small-cell lung cancer (NSCLC) represents a major goal of clinical treatment. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in cell cycle progression and is associated with oncogenesis in a large spectrum of cancer types, including NSCLC...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Li, Lifeng, Xue, Wenhua, Shen, Zhibo, Liu, Jie, Hu, Min, Cheng, Zhenyong, Wang, Yuxing, Chen, Yulu, Chang, Hao, Liu, Yingyi, Liu, Bin, Zhao, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369516/
https://ncbi.nlm.nih.gov/pubmed/32728610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.06.013
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