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p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates
Glutamine synthetase (GS) plays an essential role in metabolism by catalyzing the synthesis of glutamine from glutamate and ammonia. Our recent study showed that CRBN, a direct protein target for the teratogenic and antitumor activities of immunomodulatory drugs such as thalidomide, lenalidomide, an...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389304/ https://ncbi.nlm.nih.gov/pubmed/28320958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700949114 |
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