The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are implicated in many diseases including cancer. In mammals, mitophagy is mediated by BNIP3L (also known as NIX) that is a dual regulator of mitochondrial turnover and programmed...

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Publicado no:Acta Pharmacol Sin
Main Authors: Hao, Bing-bing, Li, Xiao-jing, Jia, Xing-long, Wang, Yu-xing, Zhai, Lin-hui, Li, Duan-zhuo, Liu, Jie, Zhang, Die, Chen, Yu-lu, Xu, Yong-hu, Lee, Sang-kyu, Xu, Guo-feng, Chen, Xiao-hua, Dang, Yong-jun, Liu, Bin, Tan, Min-jia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608331/
https://ncbi.nlm.nih.gov/pubmed/32210356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-0367-9
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