SMALL EXTRACELLULAR VESICLE REGULATION OF MITOCHONDRIAL DYNAMICS REPROGRAMS A HYPOXIC TUMOR MICROENVIRONMENT

The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer progression, but its regulators have remained elusive. Here, we show that breast cancer cells maintained in hypoxia release small extracellular vesicles (sEV) that activate mitochondrial dynamics, stimulate mi...

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Publicado en:Dev Cell
Autores principales: Bertolini, Irene, Ghosh, Jagadish C., Kossenkov, Andrew V., Mulugu, Sudheer, Krishn, Shiv Ram, Vaira, Valentina, Qin, Jun, Plow, Edward F., Languino, Lucia R., Altieri, Dario C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606608/
https://ncbi.nlm.nih.gov/pubmed/32780991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.07.014
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