Evaluation of radioiodinated protein conjugates and their potential metabolites containing lysine-urea-glutamate (LuG), PEG and closo-decaborate(2-) as models for targeting astatine-211 to metastatic prostate cancer.

INTRODUCTION: The use of lysine-urea-glutamate (LuG) for targeting the PSMA antigen on prostate cancer (PCa) is a promising method for delivering the alpha particle-emitting radionuclide astatine-211 ((211)At) to metastatic PCa. High kidney localization has been a problem with radiolabeled LuG deriv...

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Publicado no:Nucl Med Biol
Main Authors: Li, Yawen, Chyan, Ming-Kuan, Hamlin, Donald K., Nguyen, Holly, Vessella, Robert, Wilbur, D. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606587/
https://ncbi.nlm.nih.gov/pubmed/32409263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2020.04.005
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