A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

K777 is a di-peptide analog that contains an electrophilic vinyl-sulfone moiety and is a potent, covalent inactivator of cathepsins. Vero E6, HeLa/ACE2, Caco-2, A549/ACE2, and Calu-3, cells were exposed to SARS-CoV-2, and then treated with K777. K777 reduced viral infectivity with EC(50) values of i...

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Publicat a:bioRxiv
Autors principals: Mellott, Drake M., Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C., Kostomiris, Demetrios H., Hsu, Jason, Zhu, Jiyun, Taylor, Zane W., Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A., Skinner, Danielle, Hirata, Ken, Beck, Sungjun, Carlin, Aaron F., Clark, Alex E., Beretta, Laura, Maneval, Daniel, Frueh, Felix, Hurst, Brett L., Wang, Hong, Kocurek, Klaudia I., Raushel, Frank M., O’Donoghue, Anthony J., de Siqueira-Neto, Jair Lage, Meek, Thomas D., McKerrow, James H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605553/
https://ncbi.nlm.nih.gov/pubmed/33140046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.23.347534
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