Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provid...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Chenna, Bala C., Li, Linfeng, Mellott, Drake M., Zhai, Xiang, Siqueira-Neto, Jair L., Alvarez, Claudia Calvet, Bernatchez, Jean A., Desormeaux, Emily, Hernandez, Elizabeth Alvarez, Gomez, Jana, McKerrow, James H., Cruz-Reyes, Jorge, Meek, Thomas D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261474/
https://ncbi.nlm.nih.gov/pubmed/32125159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b02078
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