IL-4Rα signaling in CD4(+)CD25(+)FoxP3(+) T regulatory cells restrains airway inflammation via limiting local tissue IL-33

Impaired tolerance to innocuous particles during allergic asthma has been linked to increased plasticity of FoxP3(+) regulatory T cells (Tregs) reprogramming into pathogenic effector cells, thus exacerbating airway disease. However, failure of tolerance mechanisms is driven by Th2 inflammatory signa...

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Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Khumalo, Jermaine, Kirstein, Frank, Hadebe, Sabelo, Brombacher, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605533/
https://ncbi.nlm.nih.gov/pubmed/32931477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136206
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