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Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load
BACKGROUND: B cells play an important role in allergies through secretion of IgE. IL-4 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE secretion, and airway hyperresponsiveness. IL-4 activation of B cells is essential for class switching and contributes to...
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| Gepubliceerd in: | J Allergy Clin Immunol |
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| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Mosby
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8253118/ https://ncbi.nlm.nih.gov/pubmed/33383090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.12.635 |
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